|
Reaction
Facilities
|
| |
|
| Scale: |
From
milligram scale up to 20 l capacity. |
| Temperature: |
-80
°C to 225-250 °C |
| Photochemical
Reactor: |
Up
to 1 l capacity. |
| High
Pressure Reactor: |
We
have access to a high-pressure reactor (autoclave) with a 1
l capacity, operating up to 200 bar and 300 °C, and also
to a high pressure hydrogenation apparatus with a 2 l capacity. |
| Flash
vacuum pyrolysis: |
We
have a large flash vacuum pyrolysis rig
with which we can pyrolyse 50 to 100 g in one run, and which
is capable of handling non-condensable extruded gases (e.g.
nitrogen). |
|
Using the above facilities, we can perform the majority of
standard organic reactions, including atmospheric pressure
catalytic hydrogenation, Balz-Schiemann fluorinations, aromatic
chlorinations and brominations, Grignard reactions, butyl
lithium reactions, liquid ammonia reactions, reactions involving
inorganic cyanides, etc.
|
|
Isolation
and Separation Facilities
|
| TLC: |
Analytical
and preparative. |
| Flash-Column
Chromatography: |
Up
to 4 in diameter column (1 m long), with a 6 in diameter column
available. |
| Distillation: |
High-vacuum
(oil-pump) distillation available up to 5 l capacity.
|
| |
|
Instrumentation
|
In House
|
| I.R. |
Lumex InfraLum FT-02 FT-IR Spectrometer. |
| G.C. |
Shimadzu
GC15A with Philips PU4811 Integrator. |
| HPLC |
DuPont
system with a selection of Reverse-phase and Normal-phase columns. |
External
|
| N.M.R. |
(1H,
19F, 13C, 31P etc., 250-400
MHz) usually with 'same day' service. |
| M.S.
(including G.C./M.S. and HPLC/M.S.) |
Usually
with 'same-day' service. |
| Elemental
Analysis |
Usually
with 'same-day' service. |
| U.V. |
If
required. |
|
